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Prof. Dr. Burghardt Wittig
Chairman, Scientific & Strategy Board
MOLOGEN AG - Active immune therapies against cancer MGN1703 and MGN1601.
MOLOGEN’S lead products are MGN1703 and MGN1601. MGN1703 is a DNA-based cancer immuno-therapy with an outstanding safety profile. The drug is currently being investigated in a clinical trial phase II/III for the treatment of metastatic colorectal cancer. MGN1601 is a cancer vaccine against renal cell caner. In a clinical phase I/II trial the drug demonstrated a very good tolerability and showed first efficacy.

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Cancer immunotherapies, Cancer immunotherapies: from not even mentioned in 2000 to an emerging hallmark in 2011
MIDGE, dSLIM, DNA-based, immunomodulator, Proprietary technologies: MIDGE and dSLIM
Plasmid, litigation, digestion, purification, Proprietary technologies: MIDGE production
minimalistic linear expression vectors, anti-vector immunity, necleotides, MIDGE: minimalistic linear expression vectors
Ligase, Synthetic DNA, Exonuclease, Proprietary technologies: dSLIM production
stem-loop immunomodulator, single-stranded DNA loop, nucleotides, Molecular Pattern, , dSLIM: double stem-loop immunomodulator
adjuvant and palliative tumor therapy, Radiation / Chemotherapy, GM-CSF, allogeneic tumor cells, tumor associated antigens, monotherapy, Subcutaneous injection of MGN1703, Intradermal injection of MGN1601, MIDGE and dSLIM: adjuvant and palliative tumor therapy
Product, Research, Pre-Clinic, Phase I ,Phase II, Phase III, Approval, ONCOLOGY, MGN1703-CRC, MGN1703-NSCLC, MGN1601-RCC, INFECTIOUS DISEASES, Advanced product pipeline: MGN1703 in colorectal cancer, MGN1603 in renal cancer
Therapeutic vaccination against cancer, MGN1601, mechanism of action, allogeneic tumor cells, MIDGE in MGN1601, dSLIM of MGN1601, Therapeutic vaccination against cancer: proposed mechanism of action of MGN1601
MGN1601 MGN1601, renal cancer, phase Ib/IIa, Intra-dermal injection, Endpoints, Safety, Pharmacodynamics, , MGN1601 in renal cancer (RCC): ASET trial design
Therapeutic immunomodulation MGN1703 against cancer, MGN1703, chemotherapy, Therapeutic immunomodulation against cancer
MGN1703 MGN1703, colorectal carcinoma, phase II/III trial, Metastatic colorectal, Endpoints, Placebo, MGN1703 in colorectal carcinoma (CRC): IMPACT trial design
DNA-medicine, platform technologies, DNA- and cell-based cancer therapies, product pipeline, Stock Exchange:, MOLOGEN AG - Summary
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