Pre-Clinical and Clinical Development of Atu027, a Liposomal siRNA, for Therapy in Oncology video

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Silence Therapeutics AG (SNL)

Dr. Klaus Giese

Chief Scientific Officer

Germany

Pre-Clinical and Clinical Development of Atu027, a Liposomal siRNA, for Therapy in Oncology

Atu027, a novel RNAi therapeutic composed of liposomally formulated siRNA, is currently being tested in a Phase I clinical trial in oncology. This investigational drug targets the expression of PKN3 in the vascular endothelium and shows inhibition of tumor growth and strong anti-metastatic activity in various pre-clinical models. Latest developments on Atu027 will be discussed.

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